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KMID : 0385520160290020094
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Analytical Science & Technology
2016 Volume.29 No. 2 p.94 ~ p.103
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Development of analytical method for determination of spinetoram residues in livestock using LC-MS/MS
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Ko Ah-Young
Do Jung-Ah
Jang Jin
Lee Eun-Hyang
Ju Yun-ji
Kim Hee-Jeong
Kim Ji-Young
Chang Moon-Ik
Rhee Gyu-Sik
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Abstract
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An analytical method was developed to determine the amount of spinetoram (spinetoram J and spinetoram L) in livestock samples. The spinetoram was extracted with acetonitrile and purified through a primary secondary amine (PSA) sorbent. The spinetoram residues were then quantified and confirmed using a liquid chromatography?tandem mass spectrometer (LC-MS/MS) in the positive ion mode using multiple reactions monitoring (MRM). Matrix-matched calibration curves were linear over the calibration ranges (0.005-0.5 mg/kg) into a blank extract with r2 > 0.994. The limits of detection and quantification were 0.002 and 0.01 mg/kg, respectively. The recovery results of spinetram ranged between 81.9-106.4% at different concentration levels (LOQ, 10LOQ, 50LOQ, n
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KEYWORD
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spinetoram, LC-MS/MS, analytical method, livestock,
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